The first World Series Game 7 in four seasons saw a rematch of the Game 4 starters. Jack Morris returned to the mound for his third start of the Series for the Twins while John Smoltz made his second for the Braves. Going into the game, this Series had been regarded as one of the best ever. The seventh game would reinforce that point. A symbolic moment for the Series occurred on the first at-bat when Braves leadoff hitter Lonnie Smith shook hands with Twins catcher Brian Harper just before stepping up to the plate.

Neither team was able to score a run early on. The Twins had their first opportunity in the bottom of the third inning, when Dan Gladden doubled and advanced to third on a flyout by Chuck Knoblauch. But Smoltz struck out Puckett to end the inning. The Braves put a runner into scoring position with one out in the top of the fifth, as Mark Lemke reached third on a sacrifice bunt by Rafael Belliard and a bunt single by Smith. But Morris got Terry Pendleton to pop out and then struck out Ron Gant to end the threat.

Neither team threatened again until the eighth inning. The top of the inning included a critical defensive play, with Smith on first and nobody out. Braves manager Bobby Cox called for a hit and run with Pendleton at the plate. Pendleton responded by lacing a double into the left-center field gap, but Smith only advanced to third. Logically, Smith could have scored on the play, but after Pendleton made contact, Twins infielders Greg Gagne (shortstop) and Knoblauch (second base) feigned starting a double play by pretending to force out Smith at second. Smith hesitated, then ran to third as Pendleton headed for second. Smith claimed he hadn't been fooled by the decoy and was waiting to see if Puckett or Gladden would catch the ball. Morris later claimed the play should never have taken place. On the pitch before, with a 1–2 count on him, Pendleton appeared to swing and miss for strike three (which Morris believed Pendleton did). Pendleton appealed to home plate umpire Don Denkinger, saying that he'd foul-tipped the pitch at the plate. Denkinger turned to third base umpire Terry Tata, who confirmed the call. Nevertheless, the attempt at a rally was quashed. Morris got Gant to ground out to first baseman Kent Hrbek for the first out, which didn't permit Smith to score. David Justice was then walked intentionally, loading the bases, so Morris could pitch to the struggling Sid Bream, who only had three hits in the series. Bream also had the reputation of being one of the league's slowest runners, a fact the Twins were able to take advantage of. Morris induced Bream to ground to first. Hrbek threw home to get Smith, and catcher Brian Harper relayed the throw to first in enough time to get Bream to retire the side. Had Smith not made his baserunning error, he would not have still been on base and the Braves would have taken at least a 1–0 lead into the bottom of the eighth. As it stood, however, the teams were scoreless and the Braves would not have another baserunner in the game.

In the bottom of the eighth, Randy Bush pinch hit for Gagne to lead off for the Twins, and he singled off Smoltz, then was promptly removed from the game in favor of the faster Al Newman to pinch run. Smoltz then retired Gladden but gave up a single to Knoblauch, his eighth hit of the Series. With one out, runners on the corners, and Puckett coming to the plate, Bobby Cox elected to remove his pitcher from the game. Mike Stanton entered and was ordered to intentionally walk Puckett to load the bases. The next batter was Hrbek, who had not had a hit in quite some time and whom Stanton had struck out three times in a row. This time, Stanton got Hrbek to hit a relatively soft line drive to Mark Lemke, who then stepped on second to double-up Knoblauch. The game continued with no score.

The Braves went down in order in the top of the ninth, as Morris retired Brian Hunter, Greg Olson, and Lemke. The Twins, with a chance to win the game in their final at bat, led off with a Chili Davis single. After Jarvis Brown came in to run for Davis, Harper attempted to move him over with a bunt down the first base line. Stanton misstepped coming to play the bunt, allowing Harper to reach base without a play. To make matters worse for Atlanta, Stanton's misstep caused him to strain a muscle in his back, and he had to be removed from the game. Cox was forced to bring in Alejandro Peña to pitch to Shane Mack. Despite his earlier struggles, Peña induced a ground ball double play to record the first two outs. He then gave an intentional walk to Mike Pagliarulo and struck out pinch hitter Paul Sorrento to send the game into extra innings.

Refusing to come out of the game, Morris took to the hill for the top of the tenth. A Twin Cities sports writer wrote that on that night, "[Morris] could have outlasted Methuselah." He successfully rebuffed several attempts by manager Tom Kelly to remove him during the game, and was also supported by pitching coach Dick Such, as he remained on the mound from the first pitch to the last. And as he had been for most of the night, Morris was effective, retiring Blauser, Smith, and Pendleton in order. Morris threw 126 pitches in the game.

Peña faced Gladden to start the bottom half of the inning, and the Twins' leadoff hitter lifted a fly ball to left field after breaking his bat upon the impact. The ball landed in front of the charging Hunter for a bloop hit, and the ball then took a high bounce that Hunter was unable to field. Gant backed up the play and caught the hop, but Gladden dashed to second and beat Gant's throw to the bag. Kelly then called for a sacrifice bunt, and Knoblauch executed to put the winning run on third with one out. As he'd done in the eighth, Cox called for an intentional walk to the resurgent Puckett. Hrbek, who had not gotten a hit in his last sixteen at-bats dating back to his single in the eighth inning of Game 3, was next up, and Brown would be scheduled after Hrbek since Brown had pinch-run for the power-hitting Davis. Despite Hrbek's .115 average in the Series and lack of baserunning speed, and despite the fact that the Braves had left-hander Kent Mercker and another pitcher warming up in the bullpen, Cox decided to call a second consecutive intentional walk, loading the bases to set up a force play at home plate.

This left Kelly with a tough decision, as Brown did not hit well and had not yet gotten a hit in the Series. Entering the 10^th inning, Kelly had already used four of the seven players on his bench. Then in the top half of the inning, he had inserted Scott Leius, who was normally a third baseman, into the game to play shortstop in place of pinch hitter Sorrento. This left Kelly with backup catcher Junior Ortiz and utility man Gene Larkin. Larkin was nursing an injured knee, but had one hit in three pinch hit at bats in Games 3–5. Kelly went with Larkin, who would have been the designated hitter had the game continued and would not have had to take the field. On the first pitch he saw, Larkin drove a single into deep left-center over the drawn-in outfield, scoring Gladden with the series-winning run and giving the Twins their second world championship since moving to Minnesota. Morris was the first player to embrace Gladden at the plate, followed by others. At the same time, Larkin was mobbed at first base. The two jubilant groups eventually merged in the middle of the diamond. The victorious players were soon joined by their families on the field, including Morris by his two sons. Later, the Twins players did a victory lap around the perimeter of the Metrodome field.

For the first time since 1962, a seventh game of the World Series ended with a 1–0 verdict. This Series was also the first since 1924 to end with an extra-inning seventh-game, when the home team, the Washington Senators (who would become the Twins franchise in 1961) won it in their last at-bat. The same thing would also happen in the 1997 World Series when the Florida Marlins would beat the Cleveland Indians in the eleventh inning of Game 7. This game set a World Series record for the longest scoreless tie in Game 7. Only one other World Series game went longer without a run being scored (Game 6 of the 1956 World Series went to two outs in the bottom of the 10^th before the winning run was scored).

The 1991 World Series was the second in five seasons in which the home team won all seven games in the Series. The other time this happened was in 1987, which was also won by the Twins. Game 7 of this series was the last World Series game played at the Metrodome before the Twins moved out at the end of the 2009 season, and would be the last postseason baseball game played at the venue until 2002.

Aftermath:

In one respect this series was similar to the 1987 World Series also played by the Minnesota Twins (against the St. Louis Cardinals), in that the home team won all seven games. The pattern of the home team winning each game did not occur again until the 2001 World Series between the Arizona Diamondbacks and the New York Yankees. Seven Twins players appeared in both the 1987 and 1991 Series, playing for the Twins both times: Kirby Puckett, Kent Hrbek, Greg Gagne, Dan Gladden, Gene Larkin, Randy Bush and Al Newman. In addition, the Braves' Terry Pendleton also played in the 1987 Series, as a member of the St. Louis Cardinals.

The series was also unique because of the standings of the two participating teams in the prior season: both finished the 1990 season in last place; before 1991, no league champion had ever finished the previous season in last place, yet this was the case with both the Twins and the Braves. The Twins also won the AL West Division in 1991 with every team in the division having a .500 or better record, a feat the Braves themselves would achieve when they won the National League East in 2005.

After the Twins' triumph, the 1993 Phillies, 1998 Padres, 2007 Rockies and the 2008 Rays followed previous season's last-place finishes with a World Series appearance, but fell short. However the 2013 Red Sox would join the 1991 Twins as the only teams to win the World Series a year after finishing in last place.

The Twins and the Braves have met four times in Interleague play since the 1991 World Series. In 2002 the Braves finally experienced a Metrodome win by taking two games from the Twins in a three game series, only for the Twins to sweep a three game series from the Braves at the Metrodome in 2007. The Braves ultimately finished with an all-time record of 2–8 in the stadium before it closed as a baseball venue in 2009. In 2010, the teams played a three game series at the new Target Field, in which the Braves won two out of three games. After the 1991 Series, the Twins did not play in Atlanta again until 2011 for two pre-season exhibition games at Turner Field. The Braves and Twins split the series 1–1. Then, as part of the new season-long interleague schedule, the Twins played their first regular season series against the Braves at Turner Field in May 2013; the Braves swept the three-game set.